Notes

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A collection of fragments of understanding in the pursuit of deeper questions.

Neuronal Spiking Dynamics (Hodgkin-Huxley Model)

Hodgkin-Huxley Model Mathematically models neuronal firing. Properties of the Sodium channel:

  • Depolarize neuron when open (-70mV +40mV)
  • Establish a positive feedback loop (Voltage increase Na+ channels open Voltage increase).

Properties of the Potassium channel:

  • K-channels open Voltage decrease.
  • K-channels are Voltage-dependent.
  • K-channels are slow. (Voltage increase triggers fast Na+ and positive feedback Voltage increase one millisecond later K+ open Voltage decrease).
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However, multiple other models (Fitzhugh-Nagumo, Leaky Integrate & Fire, Galves-Löcherback, HTM models) exist and can be derived.